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BONTRIL-SR (PHENDIMETRAZINE TARTRATE) CAPSULES: OVERDOSAGE

Manifestations of acute overdosage by Bontril (Phendimetrazine Tartrate) may include restlessness, hyperreflexia, tremor, rapid respiration, assaultiveness, confusion, hallucinations, panic states.

Fatigue and depression usually follow the central stimulation.

Cardiovascular effects include arrhythmias, hypertension, or hypotension and circulatory collapse. Gastrointestinal symptoms include vomiting, nausea, diarrhea, and abdominal cramps. Poisoning may result in convulsions, coma, and death.

Management of acute intoxication by Bontril Slow-Release (Phendimetrazine Tartrate) capsules is largely symptomatic and includes lavage and sedation with a barbiturate. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendation in this regard.

Acidification of the urine increases phendimetrazine tartrate excretion.

Intravenous Phentolamine (Regitine) has been suggested for possible acute, severe hypertension, if this complicates overdosage.

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